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What you Should Know Before you Buy Fioricet Online?

But you have to know what you should know before you take Fioricet and Gabapentin. What you should tell your online doctor. Normally your online prescription needs all your health conditions and medication conditions. You should complete the health questionnaires honestly. You also should know the fioricet side effects and fioricet drug interactions, Gabapentin side effects and Gabapentin drug interaction before you take Gabapentin, and Fioricet.

Fioricet Contains 325mg Acetaminophen

Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of acetaminophen a day. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

Do not use with any other drug containing acetaminophen without asking your doctor or pharmacist first. Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-cold products). Check the labels on all your medicines to see if they contain acetaminophen, and ask your pharmacist if you are unsure.

Get medical help right away if you take too much acetaminophen (overdose), even if you feel well. Overdose symptoms may include nausea, vomiting, loss of appetite, sweating, stomach/abdominal pain, extreme tiredness, yellowing eyes/skin, and dark urine.

Daily alcohol use, especially when combined with acetaminophen, may damage your liver. Avoid alcohol.

Never Overdose Fioricet

Because Fioricet contains tylenol, and over dose tylenol will damage your liver, heart, and kidneys. Acetaminophen (APAP) is the most commonly used drug for the treatment of pain and fever around the world. At the same time, APAP is capable of causing dose-related hepatocellular necrosis, responsible for nearly 500 deaths annually in the U.S. alone, as well as 100,000 calls to US Poison Control Centers, 50,000 emergency room visits and 10,000 hospitalizations per year.

IF you get too much headache, you can take other headache medicines alternatively. Never overdose it.

Fioricet Interaction

Fioricet and other drug have some drug interaction:

1. monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days.

2. antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), other pain relievers, anxiety medicines, and muscle relaxants.

3. any medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications.

Generic Fioricet is sometimes called butalbital, butalbital apap caffeine, butapap, but-apap-caff. They are all the same medicine. There are lot of Fioricet Generic manufacturers in the USA, they have different brand.

Fioricet Side Effects

Fioricet may cause serious side effects including:

  • suddenly appearing rash,
  • swelling of face, mouth or throat,
  • difficulty breathing,
  • vomiting ,
  • hives,
  • itching ,
  • fever,
  • diarrhea,
  • dark colored urine,
  • yellowing of eyes and skin (jaundice),
  • headache,
  • nausea,
  • stomach pain,
  • weight loss,
  • white or gray stool,
  • fatigue,
  • dehydration ,
  • abdominal upset,
  • skin changes,
  • sudden high blood pressure, and
  • convulsions (seizures)

Avoid eating grapefruit or drinking grapefruit juice while using Fioricet unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with Fioricet. Ask your doctor or pharmacist for more details.

You Must have the Experience of Taking Fioricet

We have our own online doctors to review and send you a Fioricet, or Gabapentin prescription. But we will not send you medicines if you have no experience of taking the prescription you ordered. You must have asked your local street doctor health checked, and send you a prescription , and you have the experience of taking Fioricet.

In another words, we only refill the prescription for you.

We Can Not Guarantee the Brands of Fioricet

There are a lot of Fioricet manufacturers and we can cannot guarantee what brand Generic Fioricet, Gabapentin you will get, but we can guarantee all the Fioricet Generic medicines, all Gabapentin medicines are USA manufactured and FDA approved. They are distributed by the US licensed pharmacists and Approved by US doctors.

The COD warehouse has several online pharmacies, and you will find the medicine bottles are sent from different US pharmacies, and different Doctors name on the bottle.

When you complete the form. Please Guarantee all information is correct, because doctors approve your prescription by your health questionnaires.  Never try to cheat the Internet because all the online pharmacies share the same database and you maybe be blacklisted if you abuse the resources.

You Must Know What is USPS COD payment (We Only Accept Money Order Payment)

Collect on Delivery (COD) is a service that allows the sender to collect from the recipient money for postage, fees, merchandise, or any combination thereof. Each COD item has an identification number, enabling delivery confirmation.

  • COD is used by senders who want to collect payment for merchandise and/or postage and fees when the item is delivered to the receiver.
  • Sender pays postage plus fees at time of mailing.
  • The mailer guarantees to pay any return postage, unless otherwise specified on the mail.
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Tracking of mailpieces using Collect on Delivery service is available using USPS Tracking® on®.

Collect on Delivery (COD) does NOT provide:

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For this website, We use COD payment. It means: you only pay money order when you have received your prescription. USPS money  order is preferred.  It is easier for us to cash it. If you pay a fake money order, you will be blacklisted by all online pharmacies. We also have VISA pharmacies in our pharmacy network. After you become our customers, we will send you a newsletter and told you the pharmacies in our network.

What is Mechanism of Action of Fioricet  ?

Fioricet is an analgesic barbiturate combo including butalbital apap caffeine.

Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervous system (CNS) depression that ranges from mild sedation to general anesthesia.1 Butalbital has a low degree of selectivity and a narrow therapeutic index.

Typically indicated to manage tension (or muscle contraction) headaches, butalbital is often combined with one or more therapeutic agents, such as acetylsalicylic acid, acetaminophen, aspirin, and caffeine. There have not been clinical trials that evaluate the clinical efficacy of butalbital in migraines  thus it is not indicated for such condition. As with other barbiturates, butalbital carries a risk of abuse or misuse potential, intoxication, hangover, tolerance, dependence, and overdosage possibly leading to death. Butalbital?containing analgesics can also produce a drug?induced headache in addition to tolerance and dependence. Due to these risks, the use of butalbital-containing combination products is typically limited for use only in cases where other medications are deemed ineffective and such usage is advised to be carefully monitored.

Butalbital is a CNS depressant that suppresses neuronal excitability, impulse conduction, and the release of neurotransmitters, similar to actions of other barbiturates. Barbiturates primarily mediate suppressive actions on polysynaptic neuronal responses by diminishing facilitation while enhancing inhibition.1 Inhibition occurs at GABAergic synapses that express GABA-A receptors, which are transmembrane chloride ion channels that bind an inhibitory neurotransmitter GABA, barbiturates, benzodiazepines, neurosteroids, and ethanol.

Upon activation, GABA-A receptors allow Cl- influx and K+ efflux into the postjunctional terminal, resulting in inhibition of the postsynaptic neuron. It is suggested that barbiturates, including butalbital, enhances GABA binding to the GABA-A receptors 11 by binding to the ?+/?? interface in the intracellular domain (ICD) as an allosteric modulator.

Additionally, barbiturates promote benzodiazepine binding to the receptor. Barbiturates potentiate GABA-induced increases in chloride conductance and depress voltage-activated calcium currents while prolonging the duration of GABA-induced chloride channel opening. Butalbital may also inhibit the excitatory effects mediated by AMPA receptors by reducing glutamate-induced depolarizations of the receptor. It is also proposed that barbiturates and opioids may potentiate the analgesic effects of each other when co-administered, although there are inconsistencies across preclinical data.

Caffeine is thought to enhance the pain-relieving effects of acetaminophen by up to 40%. In addition, it has vasoconstrictive properties, narrowing blood vessels in the brain thereby decreasing blood flow and oxygen tension (before a headache or a migraine, blood vessels tend to enlarge). This also helps to relieve pain.

Acetaminophen belongs to a class of drugs called analgesics (pain relievers) and antipyretics (fever reducers). The exact mechanism of action of acetaminophen is not known. It may reduce the production of prostaglandins in the brain. Prostaglandins are chemicals that cause inflammation and swelling. Acetaminophen relieves pain by elevating the pain threshold, that is, by requiring a greater amount of pain to develop before a person feels it. It reduces fever through its action on the heat-regulating center of the brain. Specifically, it tells the center to lower the body’s temperature when the temperature is elevated.

Is Fioricet a controlled substance?

According to the Drug Enforcement Administration (DEA), Fioricet is not a controlled substance. However, butalbital belongs to a class of drugs known as barbiturates. These drugs are habit-forming and can be abused. For this reason, it’s not recommended to take Fioricet long-term.

Is Fioricet the same as Excedrin?

Fioricet is not the same as Excedrin. Fioricet contains butalbital, which is available by prescription only. Excedrin products are available over the counter and contain different combinations of aspirin, acetaminophen, caffeine and diphenhydramine:

Excedrin Extra Strength Excedrin Migraine Excedrin Tension Headache Excedrin PM Headache
Acetaminophen 250 mg 250 mg 500 mg 250 mg
Aspirin 250 mg 250 mg 250 mg
Caffeine 65 mg 65 mg 65 mg
Diphenhydramine 38 mg

How long does Fioricet stay in your system?

Fioricet contains three different drugs. Each drug is estimated to stay in your body for a different amount of time.

  • Acetaminophen is eliminated after about 6 to 15 hours
  • Caffeine is eliminated after about 15 hours
  • Butalbital is eliminated after about 7 days

Fioricet Prescription Information

Why is this medication prescribed?

This combination of drugs is used to relieve tension headaches.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

The combination of acetaminophen, Butalbital, Caffeine comes as a capsule and tablet to take by mouth. It usually is taken every 4 hours as needed. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take acetaminophen, Butalbital, Caffeine exactly as directed. Do not take more than six tablets or capsules in 1 day. If you think that you need more to relieve your symptoms, call your doctor.

This medication can be habit-forming. Do not take a larger dose, take it more often, or for a longer period than your doctor tells you to.

What special precautions should I follow?

Before taking acetaminophen, Butalbital, Caffeine,

  • tell your doctor and pharmacist if you are allergic to acetaminophen, butalbital, caffeine, or any other drugs.
  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially anticoagulants (‘blood thinners’) such as warfarin (Coumadin), antidepressants, antihistamines, pain medications, sedatives, sleeping pills, tranquilizers, and vitamins. Many nonprescription pain relievers contain acetaminophen. Too much of this drug can be harmful.
  • tell your doctor if you have or have ever had liver disease, porphyria, or depression.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking this medication, call your doctor.
  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
  • remember that alcohol can add to the drowsiness caused by this drug.

What special dietary instructions should I follow?

Acetaminophen, Butalbital, Caffeine may cause an upset stomach. Take this medicine with food or milk.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Acetaminophen, Butalbital, Caffeine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • drowsiness
  • upset stomach
  • vomiting
  • stomach pain
  • depression
  • lightheadedness
  • confusion

If you experience any of the following symptoms, call your doctor immediately:

  • skin rash
  • itching
  • difficulty breathing

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

Mechanism of Action of Fioricet

Fioricet is a combination pain-reliever that comprises acetaminophen, butalbital, and caffeine. The specific actions of these components are as follows:

Acetaminophen: The precise mechanism of acetaminophen is not fully understood, but experts speculate that it may engage descending serotonergic inhibitory pathways in the central nervous system (CNS) and other nociceptive pathways. Nociceptive pain pertains to the discomfort resulting from physical injury or potential harm to the body, such as sports injuries or dental procedures. Acetaminophen’s ability to lower fever is attributed to its inhibition of the hypothalamic heat-regulating center.

Butalbital: Butalbital belongs to the class of drugs known as barbiturates. When utilized to alleviate pain caused by tension headaches, it is believed to work by easing muscle contractions and inducing sedation through the enhancement of the inhibitory effects of GABA, a neurotransmitter that regulates communication between brain cells.

Caffeine: Caffeine is thought to augment the pain-relieving properties of acetaminophen by as much as 40%. Furthermore, caffeine exhibits vasoconstrictive characteristics, which involve the narrowing of blood vessels in the brain, resulting in reduced blood flow and oxygen tension. This is particularly beneficial because, before a headache or migraine, blood vessels often enlarge, contributing to the discomfort. Caffeine’s actions help alleviate this pain.

Fioricet, due to its inclusion of butalbital, falls under the category of barbiturates and is also classified as a combination analgesic.

What Should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website ( for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can’t be awakened, immediately call emergency services at 911.


What other information should I know?

Keep all appointments with your doctor.

Do not let anyone else take your medication. This medication is a controlled substance. Prescriptions may be refilled only a limited number of times; ask your pharmacist if you have any questions.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Is it OK to take Fioricet every day?

Because butalbital is habit-forming, it is not recommended to take Fioricet every day. It’s possible to build up a tolerance to butalbital. Over time, higher doses may be needed to have the same effect, leading to drug dependence. Taking higher doses of Fioricet can also increase the chance of an overdose.

Fioricet is intended for occasional use every 4 hours when symptoms occur.

How long does Fioricet stay in your system?

Fioricet contains three different drugs. Each drug is estimated to stay in your body for a different amount of time.

  • Acetaminophen is eliminated after about 6 to 15 hours
  • Caffeine is eliminated after about 15 hours
  • Butalbital is eliminated after about 7 days

How much caffeine is in Fioricet?

Fioricet contains 40 mg of caffeine, similar to a cup of tea. The following shows the average amount of caffeine in some common beverages:

  • 8 oz of coffee: 80 to 100 mg of caffeine
  • 8 oz green or black tea: 30 to 50 mg of caffeine
  • 12 oz caffeinated soda: 30 to 40 mg of caffeine

Fioricet Overdose and Treatment

Butalbital Overdose:  drowsiness, confusion, and coma; respiratory depression; hypotension; and hypovolemic shock.

Acetaminophen Overdose: dose-dependent, potentially fatal hepatic necrosis is the most serious adverse effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur. Early symptoms following a potentially hepatotoxic overdose may include: nausea, vomiting, diaphoresis, and general malaise. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. In adults hepatic toxicity has rarely been reported with acute overdoses of less than 10 grams, or fatalities with less than 15 grams.

Caffeine Overdose: insomnia, restlessness, tremor, and delirium, tachycardia and extra systoles.

Barbiturates Have the Potential to Lead to Addiction

Barbiturates have the potential to lead to addiction: Tolerance, psychological reliance, and physical dependence may develop, especially with extended use of high doses of these substances. Typically, individuals addicted to barbiturates consume an average daily dose of approximately 1500 mg. As tolerance to barbiturates builds, larger quantities are required to achieve the same level of intoxication, but the tolerance to a lethal dose does not increase more than two-fold. Consequently, the gap between a dose that causes intoxication and one that can be fatal narrows. If alcohol is consumed along with barbiturates, the lethal dose of the latter is significantly lower.

When individuals abruptly stop using barbiturates, severe withdrawal symptoms such as convulsions and delirium may manifest within about 16 hours and persist for up to 5 days. Over the course of approximately 15 days, the intensity of these withdrawal symptoms gradually diminishes.

The treatment of barbiturate dependence necessitates a cautious and gradual tapering-off process. Several withdrawal methods are available for barbiturate-dependent patients. One approach is to commence treatment at the patient’s customary dosage level and then gradually reduce the daily dosage as tolerated by the individual.

Fioricet Detox

Toxicity resulting from barbiturate poisoning can lead to a range of symptoms, including drowsiness, confusion, and even coma. Other effects may include respiratory depression, hypotension (low blood pressure), and hypovolemic shock.

In cases of acetaminophen overdosage, the most severe adverse effect is potentially fatal hepatic necrosis, which occurs in a dose-dependent manner. Additionally, renal tubular necroses, hypoglycemic coma, and coagulation defects are potential outcomes. Early symptoms following a potentially hepatotoxic overdose may involve nausea, vomiting, profuse sweating, and a general sense of discomfort. Clinical and laboratory evidence of liver toxicity may not become apparent until 48 to 72 hours after ingestion.

Acute caffeine poisoning can result in various symptoms, including insomnia, restlessness, tremors, and delirium. Cardiovascular effects may include tachycardia (rapid heart rate) and extrasystoles (abnormal heartbeats).

Fioricet is known to have withdrawal symptoms when regular use is discontinued. These symptoms can decrease gradually over an estimated two-week period.  However, the safest way to proceed through withdrawal from Fioricet requires medical assistance, as withdrawal symptoms from Fioricet can be fatal if they are not properly supervised.

Detoxification is the body’s natural process of removing toxins. People who frequently use a substance never truly detoxify from the substance because they are always adding more into their system. When someone with a Fioricet use disorder chooses to seek treatment, the first thing they must do is stop taking Fioricet and let the body detoxify.

The detoxification process can be challenging, but it is a necessary part of a person’s recovery. A medically supervised detox program is important to safely remove the substance from the body. Some people choose to try “cold turkey” detoxification, which is a potentially dangerous detox approach that involves an individual abruptly halting the intake of the drug. Because of the sudden lack of the substance that the body and mind have become used to, a person can experience severe withdrawal symptoms that often result in a failed attempt at detoxing. Quitting Cold Turkey is not a recommended or an efficient way to detox from Fioricet.

There is not one specific detoxification program that works the same for everyone. To meet individual needs, The Recovery Village has staff and resources to tailor a detox approach for each client’s unique needs. At a rehabilitation facility, trained medical professionals will guide each patient through their unique treatment plan and usher them safely through their personal withdrawal symptoms.

Detox Process for Fioricet Abuse

There are two ways to detox: “cold turkey”, or by tapering, which is gradually lowering substance dosages. Many people who choose to detox on their own at home attempt the “cold turkey” method. However, a cold-turkey detox can be dangerous, because the onset of withdrawal symptoms is more severe. Because of the potential intensity of Fioricet withdrawal symptoms, the person going through detox may end up experiencing setbacks without the proper supervision and care that a rehabilitation facility can provide.

Professional medical detoxification is the safest option when it comes to beginning on the path to recovery. At The Recovery Village, clients are monitored 24/7 to ensure that withdrawal is as comfortable as possible, that their vitals are at healthy levels and that they are not experiencing any life-threatening symptoms.

The primary risks during detox include dehydration and delirium tremens. Severe dehydration can lead to seizures,, which can easily become lethal, especially if they occur in an at-home environment without medical supervision. Delirium tremens can also lead to cardiac arrhythmia and respiratory failure, which can be fatal if left untreated.

Following detox, the patient is ready to begin treatment for their Fioricet use disorder. The Recovery Village offers many different treatment options including inpatient and outpatient rehab. Rehab is a proven treatment method for Fioricet addiction because it addresses both the physical and psychological sides of the disease.

fioricet over dose treatment
fioricet over dose treatment

The Treatment of Fioricet Overdose

A single or multiple overdose with this combination product is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended.

Immediate treatment includes support of cardiorespiratory function and measures to reduce drug absorption. Vomiting should be induced mechanically, or with syrup of ipecac, if the patient is alert (adequate pharyngeal and laryngeal reflexes). Oral activated charcoal (1 g/kg) should follow gastric emptying. The first dose should be accompanied by an appropriate cathartic. If repeated doses are used, the cathartic might be included with alternate doses as required. Hypotension is usually hypovolemic and should respond to fluids. Pressors should be avoided. A cuffed endotracheal tube should be inserted before gastric lavage of the unconscious patient and when necessary, to provide assisted respiration. If renal function is normal, forced diuresis may aid in the elimination of the barbiturate. Alkalinization of the urine increases renal excretion of some barbiturates, especially phenobarbital.

Meticulous attention should be given to maintaining adequate pulmonary ventilation. In severe cases of intoxication, peritoneal dialysis, or preferably hemodialysis may be considered. If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously.

If the dose of acetaminophen may have exceeded 140 mg/kg, acetylcysteine should be administered as early as possible. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion help predict acetaminophen toxicity. Do not await acetaminophen assay results before initiating treatment. Hepatic enzymes should be obtained initially, and repeated at 24-hour intervals.

Methemoglobinemia over 30% should be treated with methylene blue by slow intravenous administration.

Toxic Doses (for adults)

Butalbital: toxic dose 1 g (20 tablets)
Acetaminophen: toxic dose 10 g (30 tablets)
Caffeine: toxic dose 1 g (25 tablets)

In all cases of suspected overdosage, call your Regional Poison Control Center to obtain the most up-to-date information about the treatment of overdosage. Telephone numbers of certified Regional Poison Control Centers are listed in the Physicians’ Desk Reference®*.


Brand names

  • Alagesic®
  • Americet®
  • Anolor®
  • Anoquan®
  • Arcet®
  • Dolgic®
  • Dolmar®
  • Endolor®
  • Esgic®
  • Ezol®
  • Femcet®
  • Fioricet®
  • Fiorpap®
  • G-1®
  • Ide-cet®
  • Isocet®
  • Margesic®
  • Medigesic®
  • Minotal®
  • Mygracet®
  • Nonbac®
  • Pacaps®
  • Pharmagesic®
  • Quala Cet®
  • Repan®
  • Tenake®
  • Tencet®
  • Triad®
  • Two-Dyne®
  • Zebutal®

Brand names of combination products

  • Esgic® Plus (containing Acetaminophen, Butalbital, Caffeine, Codeine)
  • Geone® (containing Acetaminophen, Butalbital, Caffeine)
  • Orbivan® (containing Acetaminophen, Butalbital, Caffeine)
  • Fioricet® with Codeine (containing Acetaminophen, Butalbital, Caffeine, Codeine)
  • Phrenilin® with Caffeine and Codeine (containing Acetaminophen, Butalbital, Caffeine, Codeine)

This branded product is no longer on the market. Generic alternatives may be available.

Last Revised – 05/15/2019